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Article

Differential expression of c-myc and c-fos oncogenes during the differentiation of human leukemic cells by Ara-C.

Journal of biological regulators and homeostatic agents - 1 Jan 2000

Chomienne C, Emanoil-Ravier R, Balitrand N, Garcette M, Degos L, Abita J P

Abstract excerpt

1-B-D-arabinofuranosyl cytosine (Ara-C) is, at very low concentrations, an inducer of monocytic differentiation of human leukemic cells. By what mechanisms this differentiation is obtained and how the monocytic pathway is determined, is not yet understood. We studied the effect of Ara-C on the RNA transcript levels of two c-oncogenes often associated to cell proliferation and differentiation. In the monoblastic...

Topics

Cell Division
Cell Line
Cell Transformation, Neoplastic
Cytarabine
Gene Expression Regulation
Humans
Leukemia, Promyelocytic, Acute
Oncogenes
Phenotype
RNA
Transcription, Genetic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Tretinoin

Tumor Cells, Cultured

Source

Identifiers

PMID: 2461052

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-2461052-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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