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Article

High frequency somatic mutations in RASSF1A in nasopharyngeal carcinoma.

Cancer biology & therapy - 1 Oct 2005

Pan Zhi-Gang, Kashuba V I, Liu Xiao-Qiong, Shao Jian-Yong, Zhang Ru-Hua, Jiang Ju-Hong, Guo Can, Zabarovsky Eugene, Ernberg Ingemar, Zeng Yi-Xin

Abstract excerpt

High frequency loss of 3p21.3 region is a common event in various kinds of tumors including nasopharyngeal carcinoma (NPC). RASSF1A has been identified as a putative tumor suppressor gene residing in this region. Chromosome alterations and epigenetic changes are commonly observed as mechanisms for inactivation of RASSF1A function. In this study, we applied the PCR-cloning-sequencing strategy to examine somatic...

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PMID: 16096369
DOI: 10.4161/cbt.4.10.2023

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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