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Article

Endothelin-1 Pathway Polymorphisms and Outcomes in Pulmonary Arterial Hypertension.

American journal of respiratory and critical care medicine - 1 Dec 2015

Benza Raymond L, Gomberg-Maitland Mardi, Demarco Teresa, Frost Adaani E, Torbicki Adam, Langleben David, Pulido Tomas, Correa-Jaque Priscilla, Passineau Michael J, Wiener Howard W, Tamari Mayumi, Hirota Tomomitsu, Kubo Michiaki, Tiwari Hemant K

Abstract excerpt

RATIONALE: Pulmonary arterial hypertension (PAH) is a progressive fatal disease. Variable response and tolerability to PAH therapeutics suggests that genetic differences may influence outcomes. The endothelin pathway is central to pulmonary vascular function, and several polymorphisms and/or mutations in the genes coding for endothelin (ET)-1 and its receptors correlate with the clinical manifestations of other...

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Identifiers

PMID: 26252367
DOI: 10.1164/rccm.201501-0196OC
PMCID: PMC4731699

Genes

PAH

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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