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Article

Gambiense human african trypanosomiasis and immunological memory: effect on phenotypic lymphocyte profiles and humoral immunity.

PLoS pathogens - 1 Mar 2014

Lejon Veerle, Mumba Ngoyi Dieudonné, Kestens Luc, Boel Luc, Barbé Barbara, Kande Betu Victor, van Griensven Johan, Bottieau Emmanuel, Muyembe Tamfum Jean-Jacques, Jacobs Jan, Büscher Philippe

Abstract excerpt

In mice, experimental infection with Trypanosoma brucei causes decreased bone marrow B-cell development, abolished splenic B-cell maturation and loss of antibody mediated protection including vaccine induced memory responses. Nothing is known about this phenomenon in human African trypanosomiasis (HAT), but if occurring, it would imply the need of revaccination of HAT patients after therapy and abolish hope for a...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 24603894
DOI: 10.1371/journal.ppat.1003947
PMCID: PMC3946376

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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