Article
Systematic genetics and single-cell imaging reveal widespread morphological pleiotropy and cell-to-cell variability.
Molecular systems biology - 1 Feb 2020
Mattiazzi Usaj Mojca, Sahin Nil, Friesen Helena, Pons Carles, Usaj Matej, Masinas Myra Paz D, Shuteriqi Ermira, Shkurin Aleksei, Aloy Patrick, Morris Quaid, Boone Charles, Andrews Brenda J
Abstract excerpt
Our ability to understand the genotype-to-phenotype relationship is hindered by the lack of detailed understanding of phenotypes at a single-cell level. To systematically assess cell-to-cell phenotypic variability, we combined automated yeast genetics, high-content screening and neural network-based image analysis of single cells, focussing on genes that influence the architecture of four subcellular compartments...
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