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Article

The impact of genomic changes on treatment of lung cancer.

American journal of respiratory and critical care medicine - 1 Oct 2013

Cardarella Stephanie, Johnson Bruce E

Abstract excerpt

The remarkable success of epidermal growth factor receptor (EGFR) and anaplastic lymphoma kinase (ALK) tyrosine kinase inhibitors in patients with EGFR mutations and ALK rearrangements, respectively, introduced the era of targeted therapy in advanced non-small cell lung cancer (NSCLC), shifting treatment from platinum-based combination chemotherapy to molecularly tailored therapy. Recent genomic studies in lung...

Topics

Adenocarcinoma
Adenocarcinoma of Lung
Anaplastic Lymphoma Kinase
Antineoplastic Agents
Carcinoma, Non-Small-Cell Lung
ErbB Receptors
Genomics
Humans
Lung Neoplasms
Molecular Targeted Therapy
Mutation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Oncogene Proteins

Protein Kinase Inhibitors

Proto-Oncogene Proteins

Proto-Oncogene Proteins B-raf

Proto-Oncogene Proteins c-met

Proto-Oncogene Proteins c-ret

Proto-Oncogene Proteins p21(ras)

Source

Open in PubMed Open full text

Identifiers

PMID: 23841470
DOI: 10.1164/rccm.201305-0843PP
PMCID: PMC3826273

Genes

ALK
EGFR
BRAF
KRAS
MET
RET
ROS1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

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