Rapid targeted mutational analysis of human tumours: a clinical platform to guide personalized cancer medicine.

doi:10.1002/emmm.201000070

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Article

Rapid targeted mutational analysis of human tumours: a clinical platform to guide personalized cancer medicine.

EMBO molecular medicine - 1 May 2010

Dias-Santagata Dora, Akhavanfard Sara, David Serena S, Vernovsky Kathy, Kuhlmann Georgiana, Boisvert Susan L, Stubbs Hannah, McDermott Ultan, Settleman Jeffrey, Kwak Eunice L, Clark Jeffrey W, Isakoff Steven J, Sequist Lecia V, Engelman Jeffrey A, Lynch Thomas J, Haber Daniel A, Louis David N, Ellisen Leif W, Borger Darrell R, Iafrate A John

Abstract excerpt

Targeted cancer therapy requires the rapid and accurate identification of genetic abnormalities predictive of therapeutic response. We sought to develop a high-throughput genotyping platform that would allow prospective patient selection to the best available therapies, and that could readily and inexpensively be adopted by most clinical laboratories. We developed a highly sensitive multiplexed clinical assay...

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Identifiers

PMID: 20432502
DOI: 10.1002/emmm.201000070
PMCID: PMC3377316

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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