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Article

Current evidence on the relationship between polymorphisms in the COX-2 gene and breast cancer risk: a meta-analysis.

Breast cancer research and treatment - 1 Jul 2010

Yu Ke-Da, Chen Ao-Xiang, Yang Chen, Qiu Li-Xin, Fan Lei, Xu Wen-Huan, Shao Zhi-Ming

Abstract excerpt

The association between single-nucleotide polymorphisms (SNPs) in the COX-2 gene and breast cancer risk is still ambiguous. We here try to derive a more precise estimation of the relationship by performing a meta-analysis based on currently available evidence from literature. More than 15 SNPs have been studied, and the most studied genetic variants were rs5275, rs5277, and rs20417. Crude odds ratios (ORs) with...

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PMID: 20033767
DOI: 10.1007/s10549-009-0688-3

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