Article
Genetic variation in APE1 gene promoter is associated with noise-induced hearing loss in a Chinese population.
International archives of occupational and environmental health - 1 May 2016
Shen Huanxi, Dou Jianrui, Han Lei, Bai Ying, Li Qian, Hong Zhiqiang, Shi Jian, Zhang Hengdong, Zhang Feng, Du Cheng, Tong Zhimin, Zhu Baoli
Abstract excerpt
OBJECTIVE: To investigate whether the apurinic/apyrimidinic endonuclease 1 (APE1) 1349 T>G and -656 T>G polymorphisms were associated with the risk of noise-induced hearing loss (NIHL) in a Chinese population. METHODS: The two APE1 polymorphisms were analyzed among 613 NIHL workers and 613 normal hearing workers using the minor groove binder TaqMan probe assay. RESULTS: We found that the APE1 -656 TT genotype was...
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