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Article

KIT-D816V-independent oncogenic signaling in neoplastic cells in systemic mastocytosis: role of Lyn and Btk activation and disruption by dasatinib and bosutinib.

Blood - 18 Aug 2011

Gleixner Karoline V, Mayerhofer Matthias, Cerny-Reiterer Sabine, Hörmann Gregor, Rix Uwe, Bennett Keiryn L, Hadzijusufovic Emir, Meyer Renata A, Pickl Winfried F, Gotlib Jason, Horny Hans-Peter, Reiter Andreas, Mitterbauer-Hohendanner Gerlinde, Superti-Furga Giulio, Valent Peter

Abstract excerpt

Systemic mastocytosis (SM) either presents as a malignant neoplasm with short survival or as an indolent disease with normal life expectancy. In both instances, neoplastic mast cells (MCs) harbor D816V-mutated KIT, suggesting that additional oncogenic mechanisms are involved in malignant transformation. We here describe that Lyn and Btk are phosphorylated in a KIT-independent manner in neoplastic MCs in advanced...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 21680801
DOI: 10.1182/blood-2010-06-289959

Genes

KIT

Variants

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KIT-D816V-independent oncogenic signaling in neoplastic cells in systemic mastocytosis: role of Lyn and Btk activation and disruption by dasatinib and bosutinib.PMID 21680801Read ↗

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