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Article

Antibody-Based and Cell Therapies for Advanced Mastocytosis: Established and Novel Concepts.

International journal of molecular sciences - 12 Oct 2023

Valent Peter, Akin Cem, Arock Michel, Gleixner Karoline V, Greinix Hildegard, Hermine Olivier, Horny Hans-Peter, Ivanov Daniel, Orfao Alberto, Rabitsch Werner, Reiter Andreas, Schulenburg Axel, Sotlar Karl, Sperr Wolfgang R, Ustun Celalettin

Abstract excerpt

Advanced systemic mastocytosis (SM) is a heterogeneous group of myeloid neoplasms characterized by an uncontrolled expansion of mast cells (MC) in one or more internal organs, SM-induced tissue damage, and poor prognosis. Advanced SM can be categorized into aggressive SM (ASM), MC leukemia (MCL), and SM with an associated hematologic neoplasm (SM-AHN). In a vast majority of all patients, neoplastic cells display...

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PMID: 37894806
DOI: 10.3390/ijms242015125
PMCID: PMC10607143

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