Article
A 3'-UTR polymorphism in the oxidized LDL receptor 1 gene increases Abeta40 load as cerebral amyloid angiopathy in Alzheimer's disease.
Acta neuropathologica - 1 Jan 2006
Shi Jing, Tian Jinzhou, Pritchard Antonia, Lendon Corinne, Lambert Jean-Charles, Iwatsubo Takeshi, Mann David M A
Abstract excerpt
It is presently unclear whether polymorphic variations in the oxidized low-density lipoprotein receptor 1 (OLR1), or low-density lipoprotein receptor-related protein 1 (LRP1), genes act as risk factors for Alzheimer's disease (AD). In the present study, we have investigated the extent of amyloid beta protein (Abeta) deposition as cerebral amyloid angiopathy (CAA) or senile plaques (SP) in relationship to OLR1...
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