Article
Fertilization-induced K63-linked ubiquitylation mediates clearance of maternal membrane proteins.
Development (Cambridge, England) - 1 Mar 2014
Sato Miyuki, Konuma Ryosuke, Sato Katsuya, Tomura Kotone, Sato Ken
Abstract excerpt
In Caenorhabditis elegans, fertilization triggers endocytosis and rapid turnover of maternal surface membrane proteins in lysosomes, although the precise mechanism of this inducible endocytosis is unknown. We found that high levels of K63-linked ubiquitin chains transiently accumulated on endosom...
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