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Osteoblast Lineage Support of Hematopoiesis in Health and Disease

1 Dec 2020

Abstract excerpt

In mammals, hematopoiesis migrates to the bone marrow during embryogenesis coincident with the appearance of mineralized bone, where hematopoietic stem cells (HSCs) and their progeny are maintained by the surrounding microenvironment or niche, and sustain the entirety of the hematopoietic system. Genetic manipulation of niche factors and advances in cell lineage tracing techniques have implicated cells of both...

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PMID: 35983701
DOI: 10.1002/jbmr.4678

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