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Article

ERBB family fusions are recurrent and actionable oncogenic targets across cancer types

24 Apr 2023

Abstract excerpt

Purpose Gene fusions involving receptor tyrosine kinases (RTKs) define an important class of genomic alterations with many successful targeted therapies now approved for ALK, ROS1, RET and NTRK gene fusions. Fusions involving the ERBB family of RTKs have been sporadically reported, but their frequency has not yet been comprehensively analyzed and functional characterization is lacking on many types of ERBB...

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PMID: 37168365
DOI: 10.3389/fonc.2023.1115405

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