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Article

Mutation or loss of p53 differentially modifies TGFβ action in ovarian cancer.

PloS one - 1 Jan 2014

Ó hAinmhire Eoghainín, Quartuccio Suzanne M, Cheng Whay, Ahmed Roshan A, King Shelby M, Burdette Joanna E

Abstract excerpt

Ovarian cancer is the most lethal gynecological disease affecting women in the US. The Cancer Genome Atlas Network identified p53 mutations in 96% of high-grade serous ovarian carcinomas, demonstrating its critical role. Additionally, the Transforming Growth Factor Beta (TGFβ) pathway is dysfunctional in various malignancies, including ovarian cancer. This study investigated how expression of wild-type, mutant,...

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Source

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Identifiers

PMID: 24586866
DOI: 10.1371/journal.pone.0089553
PMCID: PMC3930740

Genes

DKK1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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