Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

βν integrin inhibits chronic and high level activation of JNK to repress senescence phenotypes in Drosophila adult midgut.

PloS one - 1 Jan 2014

Okumura Takashi, Takeda Koji, Taniguchi Kiichiro, Adachi-Yamada Takashi

Abstract excerpt

Proper control of adult stem cells including their proliferation and differentiation is crucial in maintaining homeostasis of well-organized tissues/organs throughout an organism's life. The Drosophila adult midgut has intestinal stem cells (ISCs), which have been exploited as a simple model system to investigate mechanisms controlling adult tissue homeostasis. Here, we found that a viable mutant of βν integrin...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cellular Senescence
Share to Embryo, Nonmammalian

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Immunoenzyme Techniques

Share to In Situ Hybridization

Share to Integrin beta Chains

Share to Intestinal Mucosa

Share to Intestines

Share to JNK Mitogen-Activated Protein Kinases

Source

Open in PubMed Open full text

Identifiers

PMID: 24586740
DOI: 10.1371/journal.pone.0089387
PMCID: PMC3930726

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

βν integrin inhibits chronic and high level activation of JNK to repress senescence phenotypes in Drosophila adult midgut.PMID 24586740Read ↗

Lifespan extension by preserving proliferative homeostasis in Drosophila.Semantic proximity Read ↗

Markers and Methods to Study Adult Midgut Stem Cells.Semantic proximity Read ↗

Identification and characterisation of cell intrinsic mechanisms regulating intestinal stem cell behaviour during acute damageSemantic proximity Read ↗

MK2-dependent p38b signalling protects Drosophila hindgut enterocytes against JNK-induced apoptosis under chronic stress.Semantic proximity Read ↗

Frequent Somatic Mutation in Adult Intestinal Stem Cells Drives Neoplasia and Genetic Mosaicism during Aging.Semantic proximity Read ↗

Re-entry into mitosis and regeneration of intestinal stem cells through enteroblast dedifferentiation in <i>Drosophila</i> midgutsSemantic proximity Read ↗

Identification of a new allele of O-fucosyltransferase 1 involved in Drosophila intestinal stem cell regulation.Semantic proximity Read ↗

Debra-mediated Ci degradation controls tissue homeostasis in Drosophila adult midgut.Semantic proximity Read ↗

Drosophila's contribution to stem cell researchSemantic proximity Read ↗

Pathogenic stimulation of intestinal stem cell response in Drosophila.Semantic proximity Read ↗

Nipped-A regulates intestinal stem cell proliferation in Drosophila.Semantic proximity Read ↗

Integration of UPRER and Oxidative Stress Signaling in the Control of Intestinal Stem Cell ProliferationSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.