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Article

Debra-mediated Ci degradation controls tissue homeostasis in Drosophila adult midgut.

Stem cell reports - 11 Feb 2014

Li Zhouhua, Guo Yueqin, Han Lili, Zhang Yan, Shi Lai, Huang Xudong, Lin Xinhua

Abstract excerpt

Adult tissue homeostasis is maintained by resident stem cells and their progeny. However, the underlying mechanisms that control tissue homeostasis are not fully understood. Here, we demonstrate that Debra-mediated Ci degradation is important for intestinal stem cell (ISC) proliferation in Drosophila adult midgut. Debra inhibition leads to increased ISC activity and tissue homeostasis loss, phenocopying defects...

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Source

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Identifiers

PMID: 24527387
DOI: 10.1016/j.stemcr.2013.12.011
PMCID: PMC3923220

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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