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Article

Polymorphisms and haplotypes of the CYP2B6 detoxification gene in the predisposition of Acute Myeloid Leukemia (AML) and induction of its cytogenetic abnormalities.

Cancer genetics - 1 Nov 2016

Daraki Aggeliki, Kakosaiou Katerina, Zachaki Sophia, Sambani Constantina, Aleporou-Marinou Vassiliki, Kollia Panagoula, Manola Kalliopi N

Abstract excerpt

CYP2B6 is a polymorphic detoxification gene which plays a vital role in the degradation of genotoxic compounds. In this study we hypothesized that inadequate detoxification due to CYP2B6 polymorphisms may contribute to AML. To evaluate the potential impact of CYP2B6 polymorphisms on AML development and induction of its specific chromosomal abnormalities we studied C777A and A785G polymorphisms for the first time...

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Share to Chromosome Aberrations
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Leukemia, Myeloid, Acute

Share to Polymorphism, Single Nucleotide

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Identifiers

PMID: 27865701
DOI: 10.1016/j.cancergen.2016.10.004

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