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Article

Kcnj16 knockout produces audiogenic seizures in the Dahl salt-sensitive rat.

JCI insight - 11 Jan 2021

Manis Anna D, Palygin Oleg, Isaeva Elena, Levchenko Vladislav, LaViolette Peter S, Pavlov Tengis S, Hodges Matthew R, Staruschenko Alexander

Abstract excerpt

Kir5.1 is an inwardly rectifying potassium (Kir) channel subunit abundantly expressed in the kidney and brain. We previously established the physiologic consequences of a Kcnj16 (gene encoding Kir5.1) knockout in the Dahl salt-sensitive rat (SSKcnj16-/-), which caused electrolyte/pH dysregulation and high-salt diet-induced mortality. Since Kir channel gene mutations may alter neuronal excitability and are linked...

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Source

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Identifiers

PMID: 33232300
DOI: 10.1172/jci.insight.143251
PMCID: PMC7821607

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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