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Article

Hyperactivity and dopamine D1 receptor activation in mice lacking girk2 channels.

Psychopharmacology - 1 Feb 2002

Blednov Y A, Stoffel M, Cooper R, Wallace D, Mane N, Harris R A

Abstract excerpt

RATIONALE: G-protein-coupled inwardly rectifying potassium channels (GIRKs) regulate synaptic transmission and neuronal firing rates. Co-localization of GIRK2 channels and dopamine receptors in the mesolimbic system suggests a role in regulation of motor activity. OBJECTIVES: To explore the role of GIRK channels in the regulation of motor behavior. METHODS: GIRK2 null mutant mice (knockout) were used. Locomotor...

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Share to Dose-Response Relationship, Drug
Share to G Protein-Coupled Inwardly-Rectifying Potassium Channels

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 11823889
DOI: 10.1007/s00213-001-0937-6

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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