NOTCH1 mutation and its prognostic significance in Chinese chronic lymphocytic leukemia: a retrospective study of 317 cases.

doi:10.1002/cam4.1396

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Article

NOTCH1 mutation and its prognostic significance in Chinese chronic lymphocytic leukemia: a retrospective study of 317 cases.

Cancer medicine - 1 May 2018

Zou Yixin, Fan Lei, Xia Yi, Miao Yi, Wu Wei, Cao Lei, Wu Jiazhu, Zhu Huayuan, Qiao Chun, Wang Li, Xu Wei, Li Jianyong

Abstract excerpt

The proto-oncogene NOTCH1 is frequently mutated in around 10% of patients with chronic lymphocytic leukemia (CLL). This study analyzed NOTCH1 mutation status of 317 Chinese patients with CLL by Sanger sequencing. The frequencies of NOTCH1 mutation in the PEST (proline (P), glutamic acid (E), serine (S), threonine (T)-rich protein sequence) domain and the 3' untranslated regions (UTR) were 8.2% and 0.9%, with the...

Topics

3' Untranslated Regions
Adult
Aged
Aged, 80 and over
Asian People
China
Chromosomes, Human, Pair 12
Female
Humans
Immunoglobulin Heavy Chains
Immunoglobulin Variable Region

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Leukemia, Lymphocytic, Chronic, B-Cell

Male

Middle Aged

Mutation

Polymorphism, Single Nucleotide

Prognosis

Proto-Oncogene Mas

Source

Open in PubMed Open full text

Identifiers

PMID: 29573199
DOI: 10.1002/cam4.1396
PMCID: PMC5943423

Genes

NOTCH1

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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