Article
Mutations of NOTCH1 are an independent predictor of survival in chronic lymphocytic leukemia.
Blood - 12 Jan 2012
Rossi Davide, Rasi Silvia, Fabbri Giulia, Spina Valeria, Fangazio Marco, Forconi Francesco, Marasca Roberto, Laurenti Luca, Bruscaggin Alessio, Cerri Michaela, Monti Sara, Cresta Stefania, Famà Rosella, De Paoli Lorenzo, Bulian Pietro, Gattei Valter, Guarini Anna, Deaglio Silvia, Capello Daniela, Rabadan Raul, Pasqualucci Laura, Dalla-Favera Riccardo, Foà Robin, Gaidano Gianluca
Abstract excerpt
Analysis of the chronic lymphocytic leukemia (CLL) coding genome has recently disclosed that the NOTCH1 proto-oncogene is recurrently mutated at CLL presentation. Here, we assessed the prognostic role of NOTCH1 mutations in CLL. Two series of newly diagnosed CLL were used as training (n = 309) and validation (n = 230) cohorts. NOTCH1 mutations occurred in 11.0% and 11.3% CLL of the training and validation series,...
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