Article
Genomic characterization of high-count MBL cases indicates that early detection of driver mutations and subclonal expansion are predictors of adverse clinical outcome.
Leukemia - 1 Jan 2017
Barrio S, Shanafelt T D, Ojha J, Chaffee K G, Secreto C, Kortüm K M, Pathangey S, Van-Dyke D L, Slager S L, Fonseca R, Kay N E, Braggio E
Abstract excerpt
High-count monoclonal B-cell lymphocytosis (MBL) is an asymptomatic expansion of clonal B cells in the peripheral blood without other manifestations of chronic lymphocytic leukemia (CLL). Yearly, 1% of MBLs evolve to CLL requiring therapy; thus being critical to understand the biological events that determine which MBLs progress to intermediate/advanced CLL. In this study, we performed targeted deep sequencing on...
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