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Article

Phenotypic analysis of chemokine-driven actin reorganization in primary human neutrophils.

Assay and drug development technologies - 1 Mar 2014

Kredel Simone, Wolff Michael, Gierschik Peter, Heilker Ralf

Abstract excerpt

The chemokine-driven activation of CXC-type chemokine receptors 1/2 (CXCR1/2) and the subsequent reorganization of the neutrophilic actin are early key events in the induction of neutrophil migration toward centers of inflammation. In this study, an image analysis algorithm was developed to detect subtle chemokine-induced changes in the actin cytoskeleton of primary human neutrophils. By this means, a discrete...

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Source

Identifiers

PMID: 24579814
DOI: 10.1089/adt.2013.553

Genes

CXCR1
CXCR2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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