Article
A report of 2 new cases of MODY2 and review of the literature: implications in the search for type 2 diabetes drugs.
Metabolism: clinical and experimental - 1 Nov 2013
Shammas Christos, Neocleous Vassos, Phelan Marie M, Lian Lu-Yun, Skordis Nicos, Phylactou Leonidas A
Abstract excerpt
Glucokinase (GCK) acts as a glucose sensor and stimulates the release of insulin from pancreatic β-cells and any GCK gene mutations can lead to different forms of diabetes, such as GCK-monogenic diabetes of the young type 2 (MODY2), permanent neonatal diabetes and congenital hyperinsulinism. Many MODY2 causing mutations display a variation in the degree of severity, ranging from mild dietary-restricted forms to...
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