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Article

Glucokinase (GCK) mutations and their characterization in MODY2 children of southern Italy.

PloS one - 1 Jan 2012

Capuano Marina, Garcia-Herrero Carmen Maria, Tinto Nadia, Carluccio Carla, Capobianco Valentina, Coto Iolanda, Cola Arturo, Iafusco Dario, Franzese Adriana, Zagari Adriana, Navas Maria Angeles, Sacchetti Lucia

Abstract excerpt

Type 2 Maturity Onset Diabetes of the Young (MODY2) is a monogenic autosomal disease characterized by a primary defect in insulin secretion and hyperglycemia. It results from GCK gene mutations that impair enzyme activity. Between 2006 and 2010, we investigated GCK mutations in 66 diabetic children from southern Italy with suspected MODY2. Denaturing High Performance Liquid Chromatography (DHPLC) and sequence...

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Share to Adenosine Triphosphate
Share to Chromatography, High Pressure Liquid

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 22761713
DOI: 10.1371/journal.pone.0038906
PMCID: PMC3385652

Genes

GCK

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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