Mutations in GCK May Lead to MODY2 by Reducing Glycogen Synthesis.

doi:10.1002/adbi.202200097

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Article

Mutations in GCK May Lead to MODY2 by Reducing Glycogen Synthesis.

Advanced biology - 1 Nov 2022

Li Zongyue, Li Kunxia, Sun Yan, Jiang Xiuyun, Liu Jia, Li Jingyi, Fang Li, Li Guimei, Guan Qingbo, Xu Chao

Abstract excerpt

Dysfunction of glucokinase (GCK) caused by mutations in the GCK gene is the main cause of maturity-onset diabetes of the young type-2 (MODY2, also known as GCK-MODY), which is usually present in adolescence or young adulthood. MODY2 is characterized by mild, stable fasting hyperglycemia that presents at birth, usually 5.4-8.3 mmol L-1 , and rarely develops complications from diabetes. The treatment of MODY2...

Topics

Adolescent
Humans
Young Adult
Diabetes Mellitus, Type 2
Glucokinase
Glycogen
Hyperglycemia
Kinetics
Mutation
Child, Preschool
Male
Female

Source

Open in PubMed

Identifiers

PMID: 35770790
DOI: 10.1002/adbi.202200097

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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