Glucokinase mutations in pediatric patients with impaired fasting glucose.

doi:10.1007/s00592-017-1021-y

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Article

Glucokinase mutations in pediatric patients with impaired fasting glucose.

Acta diabetologica - 1 Oct 2017

Aloi C, Salina A, Minuto N, Tallone R, Lugani F, Mascagni A, Mazza O, Cassanello M, Maghnie M, d'Annunzio G

Abstract excerpt

AIMS: Our aim was to detect the frequency of glucokinase (GCK) gene mutations in a cohort of patients with impaired fasting glucose and to describe the clinical manifestations of identified variants. We also aimed at predicting the effect of the novel missense mutations by computational approach. METHODS: Overall 100 unrelated Italian families with impaired fasting glucose were enrolled and subdivided into two...

Topics

Adolescent
Adult
Child
Child, Preschool
Cohort Studies
Diabetes Mellitus, Type 2
Fasting
Female
Glucokinase
Glucose
Heterozygote
Humans

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Incidence

Infant

Italy

Male

Mutation, Missense

Phenotype

Source

Open in PubMed

Identifiers

PMID: 28726111
DOI: 10.1007/s00592-017-1021-y

Genes

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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