Article
Identification of eight novel glucokinase mutations in Italian children with maturity-onset diabetes of the young.
Human mutation - 1 Oct 2003
Mantovani Vilma, Salardi Silvana, Cerreta Vincenzo, Bastia Daniela, Cenci Marinella, Ragni Luca, Zucchini Stefano, Parente Raffaele, Cicognani Alessandro
Abstract excerpt
Maturity-onset diabetes of the young (MODY) is a clinically heterogeneous group of disorders characterized by early onset non-insulin-dependent diabetes mellitus, autosomal dominant inheritance, and primary defect in the function of the beta cells of the pancreas. Mutations in the glucokinase (GCK) gene account for 8%-56% of MODY, with the highest prevalences being found in the southern Europe. While screening...
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