The total burden of rare, non-synonymous exome genetic variants is not associated with childhood or late-life cognitive ability.

Abstract excerpt

Human cognitive ability shows consistent, positive associations with fitness components across the life-course. Underlying genetic variation should therefore be depleted by selection, which is not observed. Genetic variation in general cognitive ability (intelligence) could be maintained by a mutation-selection balance, with rare variants contributing to its genetic architecture. This study examines the...

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