Article

The impact of rare protein coding genetic variation on adult cognitive function

2022-06-26

Abstract excerpt

Compelling evidence suggests that cognitive function is strongly influenced by genetics. Here, we conduct a large-scale exome study to examine whether rare protein coding variants impact cognitive function in the adult population (N=485,930). We identify eight genes associated with adult cognitive function through rare coding variants with large effects. We demonstrate how the dosage of a single gene, KDM5B , may...

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Literature Corpus work: 4c4da035-b943-5aca-bfd8-4c4ebadf125e
DOI: 10.1101/2022.06.24.22276728

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