Common and rare genetic variant associations with cognitive performance across development in British birth cohorts.

doi:10.1038/s41562-026-02491-8

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Article

Common and rare genetic variant associations with cognitive performance across development in British birth cohorts.

Nature human behaviour - 1 Sept 2026

Malawsky Daniel S, Koko Mahmoud, Danacek Petr, Huang Wei, Wootton Olivia, Huang Qin Qin, Wade Emma E, Lindsay Sarah J, Arden Rosalind, Hurles Matthew E, Martin Hilary C

Abstract excerpt

Genetic variants that correlate with adult cognitive performance are also associated with rare neurodevelopmental conditions involving cognitive deficits in children. However, their association with cognition across early life remains poorly understood. Using 6,495 children from the Avon Longitudinal Study of Parents and Children, we show that, as children age, the association between cognitive ability and...

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Topics

Humans
Cognition
Genetic Variation
Child
United Kingdom
Genetic Risk Score

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Female

Longitudinal Studies

Male

Birth Cohort

Multifactorial Inheritance

Educational Status

Child, Preschool

Phenotype

Child Development

Source

Open in PubMed Open full text

Identifiers

PMID: 42432050
DOI: 10.1038/s41562-026-02491-8
PMCID: PMC13590407

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