Clinical Utility of Prospective Molecular Characterization in Advanced Endometrial Cancer.

doi:10.1158/1078-0432.CCR-18-0412

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Article

Clinical Utility of Prospective Molecular Characterization in Advanced Endometrial Cancer.

Clinical cancer research : an official journal of the American Association for Cancer Research - 1 Dec 2018

Soumerai Tara E, Donoghue Mark T A, Bandlamudi Chaitanya, Srinivasan Preethi, Chang Matthew T, Zamarin Dmitriy, Cadoo Karen A, Grisham Rachel N, O'Cearbhaill Roisin E, Tew William P, Konner Jason A, Hensley Martee L, Makker Vicky, Sabbatini Paul, Spriggs David R, Troso-Sandoval Tiffany A, Charen Alexandra Snyder, Friedman Claire, Gorsky Mila, Schweber Sarah J, Middha Sumit, Murali Rajmohan, Chiang Sarah, Park Kay J, Soslow Robert A, Ladanyi Marc, Li Bob T, Mueller Jennifer, Weigelt Britta, Zehir Ahmet, Berger Michael F, Abu-Rustum Nadeem R, Aghajanian Carol, DeLair Deborah F, Solit David B, Taylor Barry S, Hyman David M

Abstract excerpt

PURPOSE: Advanced-stage endometrial cancers have limited treatment options and poor prognosis, highlighting the need to understand genetic drivers of therapeutic vulnerabilities and/or prognostic predictors. We examined whether prospective molecular characterization of recurrent and metastatic disease can reveal grade and histology-specific differences, facilitating enrollment onto clinical trials. EXPERIMENTAL...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 30068706
DOI: 10.1158/1078-0432.CCR-18-0412
PMCID: PMC6279519

Genes

BRCA2
IMPACT
MLH1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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