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Next-generation sequencing analysis of endometrial screening liquid-based cytology specimens: a comparative study to tissue specimens.

BMC medical genomics - 11 Jul 2020

Akahane Toshiaki, Kitazono Ikumi, Yanazume Shintaro, Kamio Masaki, Togami Shinichi, Sakamoto Ippei, Nohara Sachio, Yokoyama Seiya, Kobayashi Hiroaki, Hiraki Tsubasa, Suzuki Shinsuke, Ueno Shinichi, Tanimoto Akihide

Abstract excerpt

BACKGROUND: Liquid-based cytology (LBC) is now a widely used method for cytologic screening and cancer diagnosis. Since the cells are fixed with alcohol-based fixatives, and the specimens are stored in a liquid condition, LBC specimens are suitable for genetic analyses. METHODS: Here, we established a small cancer gene panel, including 60 genes and 17 microsatellite markers for next-generation sequencing, and...

Topics

Biomarkers, Tumor
Cytodiagnosis
DNA, Neoplasm
Early Detection of Cancer
Endometrial Neoplasms
Female
Genetic Testing
High-Throughput Nucleotide Sequencing
Humans

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Liquid Biopsy

Mutation

Prognosis

Specimen Handling

Source

Open in PubMed Open full text

Identifiers

PMID: 32652986
DOI: 10.1186/s12920-020-00753-6
PMCID: PMC7353725

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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