Article
Family studies of type 1 diabetes reveal additive and epistatic effects between MGAT1 and three other polymorphisms.
Genes and immunity - 1 Apr 2014
Yu Z, Li C F, Mkhikian H, Zhou R W, Newton B L, Demetriou M
Abstract excerpt
In a recent study on multiple sclerosis (MS), we observed additive effects and epistatic interactions between variants of four genes that converge to induce T-cell hyperactivity by altering Asn-(N)-linked protein glycosylation: namely, the Golgi enzyme MGAT1, cytotoxic T-lymphocyte antigen 4 (CTLA-4), interleukin-2 receptor-α (IL2RA) and interleukin-7 receptor-α (IL7RA). As the CTLA-4, IL2RA and IL7RA variants...
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