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Article

MGAT5 alters the severity of multiple sclerosis.

Journal of neuroimmunology - 30 Mar 2010

Brynedal B, Wojcik J, Esposito F, Debailleul V, Yaouanq J, Martinelli-Boneschi F, Edan G, Comi G, Hillert J, Abderrahim H

Abstract excerpt

Multiple Sclerosis (MS) is a genetically complex immune mediated, demyelinating disease of the central nervous system. To date no genetic variants have been unambiguously linked to disease severity. We have conducted a genome wide screen, using Affymetrix Genechip 500K technology, for severity in 1040 MS patients. Two markers within MGAT5, a gene coding for a glycosylation enzyme, were found to be significantly...

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Source

Identifiers

PMID: 20117844
DOI: 10.1016/j.jneuroim.2010.01.003

Genes

MGAT5

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