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Article

An investigational antiviral drug, DAS181, effectively inhibits replication of zoonotic influenza A virus subtype H7N9 and protects mice from lethality.

The Journal of infectious diseases - 1 Aug 2014

Marjuki Henju, Mishin Vasiliy P, Chesnokov Anton P, De La Cruz Juan A, Fry Alicia M, Villanueva Julie, Gubareva Larisa V

Abstract excerpt

Human infections caused by avian influenza A virus type subtype H7N9 have been associated with substantial morbidity and mortality. Emergence of virus variants carrying markers of decreased susceptibility to neuraminidase inhibitors was reported. Here we show that DAS181 (Fludase), an antiviral drug with sialidase activity, potently inhibited replication of wild-type influenza A(H7N9) and its...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 24569063
DOI: 10.1093/infdis/jiu105
PMCID: PMC4091581

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