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Article

Protection against lethal influenza virus challenge by RNA interference <i>in vivo</i>

1 Jun 2004

Abstract excerpt

Influenza virus infection is responsible for hundreds of thousands of deaths annually. Current vaccination strategies and antiviral drugs provide limited protection; therefore, new strategies are needed. RNA interference is an effective means of suppressing virus replication in vitro. Here we demonstrate that treatment with small interfering RNAs (siRNAs) specific for highly conserved regions of the nucleoprotein...

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Identifiers

PMID: 15173583
DOI: 10.1073/pnas.0402630101

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