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Article

Inhibition of neuraminidase inhibitor-resistant influenza virus by DAS181, a novel sialidase fusion protein.

PloS one - 6 Nov 2009

Triana-Baltzer Gallen B, Gubareva Larisa V, Klimov Alexander I, Wurtman David F, Moss Ronald B, Hedlund Maria, Larson Jeffrey L, Belshe Robert B, Fang Fang

Abstract excerpt

Antiviral drug resistance for influenza therapies remains a concern due to the high prevalence of H1N1 2009 seasonal influenza isolates which display H274Y associated oseltamivir-resistance. Furthermore, the emergence of novel H1N1 raises the potential that additional reassortments can occur, resulting in drug resistant virus. Thus, additional antiviral approaches are urgently needed. DAS181 (Fludase), a...

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Identifiers

PMID: 19893749
DOI: 10.1371/journal.pone.0007838
PMCID: PMC2770896

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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