Article
Treatment of resistant influenza virus infection in a hospitalized patient with cystic fibrosis with DAS181, a host-directed antiviral.
Antiviral therapy - 1 Jan 2016
Silveira Fernanda P, Abdel-Massih Rima, Bogdanovich Tatiana, Pakstis Diana L, Routh Rebecca L, Moss Ronald B
Abstract excerpt
We report a cystic fibrosis patient infected with influenza 2009H1N1 who had persistent viral shedding and clinical deterioration despite prolonged treatment with oseltamivir and zanamivir. The patient was diagnosed with H275Y neuraminidase inhibitor resistant influenza during treatment, thus was treated for 10 days with DAS181, an investigational host-directed inhaled sialidase fusion protein. Viral clearance...
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