Article
mTOR Inhibition Suppresses Posttransplant Alloantibody Production Through Direct Inhibition of Alloprimed B Cells and Sparing of CD8+ Antibody-Suppressing T cells.
Transplantation - 1 Sept 2016
Avila Christina L, Zimmerer Jason M, Elzein Steven M, Pham Thomas A, Abdel-Rasoul Mahmoud, Bumgardner Ginny L
Abstract excerpt
BACKGROUND: De novo alloantibodies (donor-specific antibody) contribute to antibody-mediated rejection and poor long-term graft survival. Because the development of donor-specific antibody is associated with early graft loss of cell transplants and reduced long-term survival of solid organ transplants, we hypothesized that conventional immunosuppressives, calcineurin inhibitors (CNi), and mammalian target of...
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