Article
ARID5B polymorphism confers an increased risk to acquire specific MLL rearrangements in early childhood leukemia.
BMC cancer - 25 Feb 2014
Emerenciano Mariana, Barbosa Thayana Conceição, Lopes Bruno Almeida, Blunck Caroline Barbieri, Faro Alessandra, Andrade Camilla, Meyer Claus, Marschalek Rolf, Pombo-de-Oliveira Maria S
Abstract excerpt
BACKGROUND: Acute leukemia in early age (EAL) is characterized by acquired genetic alterations such as MLL rearrangements (MLL-r). The aim of this case-controlled study was to investigate whether single nucleotide polymorphisms (SNPs) of IKZF1, ARID5B, and CEBPE could be related to the onset of EAL cases (<24 months-old at diagnosis). METHODS: The SNPs (IKZF1 rs11978267, ARID5B rs10821936 and rs10994982, CEBPE...
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