Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

A splicing-dependent transcriptional checkpoint associated with prespliceosome formation.

Molecular cell - 6 Mar 2014

Chathoth Keerthi T, Barrass J David, Webb Shaun, Beggs Jean D

Abstract excerpt

There is good evidence for functional interactions between splicing and transcription in eukaryotes, but how and why these processes are coupled remain unknown. Prp5 protein (Prp5p) is an RNA-stimulated adenosine triphosphatase (ATPase) required for prespliceosome formation in yeast. We demonstrate through in vivo RNA labeling that, in addition to a splicing defect, the prp5-1 mutation causes a defect in the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adenosine Triphosphate
Share to Chromatin Immunoprecipitation
Share to DEAD-box RNA Helicases

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to RNA Polymerase II

Share to RNA Precursors

Share to RNA, Small Nuclear

Share to RNA Splicing

Share to Spliceosomes

Source

Open in PubMed Open full text

Identifiers

PMID: 24560925
DOI: 10.1016/j.molcel.2014.01.017
PMCID: PMC3988880

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

A splicing-dependent transcriptional checkpoint associated with prespliceosome formation.PMID 24560925Read ↗

ATP requirement for Prp5p function is determined by Cus2p and the structure of U2 small nuclear RNA.Semantic proximity Read ↗

Prp43p is a DEAH-box spliceosome disassembly factor essential for ribosome biogenesis.Semantic proximity Read ↗

Activation of Prp28 ATPase by phosphorylated Npl3 at a critical step of spliceosome remodeling.Semantic proximity Read ↗

Prp4 Kinase Grants the License to Splice: Control of Weak Splice Sites during Spliceosome Activation.Semantic proximity Read ↗

A novel mechanism for Prp5 function in prespliceosome formation and proofreading the branch site sequence.Semantic proximity Read ↗

Cotranscriptional spliceosome assembly dynamics and the role of U1 snRNA:5'ss base pairing in yeast.Semantic proximity Read ↗

Prp45 affects Prp22 partition in spliceosomal complexes and splicing efficiency of non-consensus substrates.Semantic proximity Read ↗

In vivo commitment to yeast cotranscriptional splicing is sensitive to transcription elongation mutants.Semantic proximity Read ↗

Extensive genetic interactions between PRP8 and PRP17/CDC40, two yeast genes involved in pre-mRNA splicing and cell cycle progression.Semantic proximity Read ↗

Spatial organization of protein-RNA interactions in the branch site-3' splice site region during pre-mRNA splicing in yeast.Semantic proximity Read ↗

prp8 mutations that cause human retinitis pigmentosa lead to a U5 snRNP maturation defect in yeast.Semantic proximity Read ↗

Competition between the ATPase Prp5 and branch region-U2 snRNA pairing modulates the fidelity of spliceosome assembly.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.