Article
Alternative splicing of the Robo3 axon guidance receptor governs the midline switch from attraction to repulsion.
Neuron - 8 May 2008
Chen Zhe, Gore Bryan B, Long Hua, Ma Le, Tessier-Lavigne Marc
Abstract excerpt
Alternative splicing provides a means to increase the complexity of gene function in numerous biological processes, including nervous system wiring. Navigating axons switch responses from attraction to repulsion at intermediate targets, allowing them to grow to each intermediate target and then to move on. The mechanisms underlying this switch remain poorly characterized. We previously showed that the Slit...
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