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Article

Differential epigenome-wide DNA methylation patterns in childhood obesity-associated asthma

16 Jul 2013

Abstract excerpt

While DNA methylation plays a role in T-helper (Th) cell maturation, its potential dysregulation in the non-atopic Th1-polarized systemic inflammation observed in obesity-associated asthma is unknown. We studied DNA methylation epigenome-wide in peripheral blood mononuclear cells (PBMCs) from 8 obese asthmatic pre-adolescent children and compared it to methylation in PBMCs from 8 children with asthma alone,...

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PMID: 23857381
DOI: 10.1038/srep02164

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