The early-life exposome modulates the effect of polymorphic inversions on DNA methylation.

doi:10.1038/s42003-022-03380-2

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The early-life exposome modulates the effect of polymorphic inversions on DNA methylation.

Communications biology - 12 May 2022

Carreras-Gallo Natàlia, Cáceres Alejandro, Balagué-Dobón Laura, Ruiz-Arenas Carlos, Andrusaityte Sandra, Carracedo Ángel, Casas Maribel, Chatzi Leda, Grazuleviciene Regina, Gutzkow Kristine Bjerve, Lepeule Johanna, Maitre Léa, Nieuwenhuijsen Mark, Slama Remy, Stratakis Nikos, Thomsen Cathrine, Urquiza Jose, Wright John, Yang Tiffany, Escaramís Geòrgia, Bustamante Mariona, Vrijheid Martine, Pérez-Jurado Luis A, González Juan R

Abstract excerpt

Polymorphic genomic inversions are chromosomal variants with intrinsic variability that play important roles in evolution, environmental adaptation, and complex traits. We investigated the DNA methylation patterns of three common human inversions, at 8p23.1, 16p11.2, and 17q21.31 in 1,009 blood samples from children from the Human Early Life Exposome (HELIX) project and in 39 prenatal heart tissue samples. We...

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PMID: 35550596
DOI: 10.1038/s42003-022-03380-2
PMCID: PMC9098634

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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