Article
Foot-and-mouth disease virus 2C is a hexameric AAA+ protein with a coordinated ATP hydrolysis mechanism.
The Journal of biological chemistry - 6 Aug 2010
Sweeney Trevor R, Cisnetto Valentina, Bose Daniel, Bailey Matthew, Wilson Jon R, Zhang Xiaodong, Belsham Graham J, Curry Stephen
Abstract excerpt
Foot-and-mouth disease virus (FMDV), a positive sense, single-stranded RNA virus, causes a highly contagious disease in cloven-hoofed livestock. Like other picornaviruses, FMDV has a conserved 2C protein assigned to the superfamily 3 helicases a group of AAA+ ATPases that has a predicted N-terminal membrane-binding amphipathic helix attached to the main ATPase domain. In infected cells, 2C is involved in the...
Topics
- Adenosine Triphosphate
- Amino Acid Motifs
- Carrier Proteins
- Catalytic Domain
- Escherichia coli
- Foot-and-Mouth Disease Virus
- Hydrolysis
- Kinetics
- Models, Biological
- Mutation