Genetic studies on the poliovirus 2C protein, an NTPase. A plausible mechanism of guanidine effect on the 2C function and evidence for the importance of 2C oligomerization.

doi:10.1016/0022-2836(94)90060-4

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Article

Genetic studies on the poliovirus 2C protein, an NTPase. A plausible mechanism of guanidine effect on the 2C function and evidence for the importance of 2C oligomerization.

Journal of molecular biology - 11 Mar 1994

Tolskaya E A, Romanova L I, Kolesnikova M S, Gmyl A P, Gorbalenya A E, Agol V I

Abstract excerpt

Poliovirus RNA replication is known to be inhibited by millimolar concentrations of guanidine. A variety of guanidine-resistant (gr) and guanidine-dependent (gd) poliovirus strains were selected, and mutations responsible for the phenotypic alterations were mapped to distinct loci of the viral NT...

Topics

Acid Anhydride Hydrolases
Amino Acid Sequence
Carrier Proteins
Consensus Sequence
Genes, Viral
Genetic Complementation Test
Guanidine
Guanidines
Molecular Sequence Data
Mutation
Nucleoside-Triphosphatase

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Poliovirus

RNA, Viral

Sequence Alignment

Sequence Homology, Amino Acid

Structure-Activity Relationship

Viral Nonstructural Proteins

Viral Structural Proteins

Source

Open in PubMed

Identifiers

PMID: 8126722
DOI: 10.1016/0022-2836(94)90060-4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-8126722-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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Genetic studies on the poliovirus 2C protein, an NTPase. A plausible mechanism of guanidine effect on the 2C function and evidence for the importance of 2C oligomerization.PMID 8126722Read ↗

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