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Article

Genetic variant in SWI/SNF complexes influences hepatocellular carcinoma risk: a new clue for the contribution of chromatin remodeling in carcinogenesis.

Scientific reports - 21 Feb 2014

Zhong Rong, Liu Li, Tian Yao, Wang Ying, Tian Jing, Zhu Bei-bei, Chen Wei, Qian Jia-ming, Zou Li, Xiao Min, Shen Na, Yang Hong, Lou Jiao, Qiu Qian, Ke Jun-tao, Lu Xing-hua, Wang Zhen-ling, Song Wei, Zhang Ti, Li Hui, Wang Li, Miao Xiao-ping

Abstract excerpt

Chromatin remodeling has been newly established as an important cancer genome characterization and recent exome and whole-genome sequencing studies of hepatocellular carcinoma (HCC) showed that recurrent inactivating mutations in SWI/SNF subunits involved in the molecular basis of hepatocarcinogenesis. To test the hypothesis that genetic variants in the key subunits of SWI/SNF complexes may contribute to HCC...

Read the complete abstract on PubMed

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Share to Carcinogenesis
Share to Carcinoma, Hepatocellular

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Chromatin Assembly and Disassembly

Share to Chromosomal Proteins, Non-Histone

Share to DNA Helicases

Share to Liver Neoplasms

Share to Nuclear Proteins

Share to SMARCB1 Protein

Source

Open in PubMed Open full text

Identifiers

PMID: 24556940
DOI: 10.1038/srep04147
PMCID: PMC3930892

Genes

SMARCA4
SMARCB1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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